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The mucosal surfaces of the Atlantic salmon: A site for viral entry and possible passive immunization.

By generating knowledge on infection routes across the mucosal surfaces and by examine alternative therapeutic strategies to prevent and reduce the risk of disease outbreaks, this application meets the priorities in the call set by the Norwegian Research Council, (HAVBRUK, Tema 2 - Frisk Fisk).Infectious disease poses a serious threat to the productivity of the aquaculture industry. Disease resistant fish strains and vaccines are valuable tools to fight diseases, but knowledge on additional therapeutic s trategies will in the future be essential to hold back present and emerging diseases and keeping a healthy and sustainable industry.With this in mind, the current project will provide fundamental insight into uptake across the mucosal surface and the pot ential of passive immunization in salmonids. To examine this possibility, specialized recombinant antibodies will be developed toward infectious pancreatic necrosis virus. The antibodies will be tested for their virus neutralizing abilities in Atlantic sa lmon, but also used as a model to examine the potential of such passive immunization in general. Passive immunization of salmon can be administrated where and when there is a high risk of infection. Such immunization systems may be very helpful, particul arly during the seawater growth stages in which vaccination through injection is not possible. Passive immunization will not, by it self, give humoral immunity, but could potentially block infection or reduce the severity of disease to give the fish suffi cient time to develop its own immune response. If an outbreak is diagnosed, these antibodies targeted toward the pathogen may have the capability restrain transmission by reducing the shedding and uptake of the pathogen.

Prosjektleder:
Erling Olaf Koppang
Institusjon:
UoH-sektor/Norges veterinærhøgskole
Aktivitetsnavn:
Havbruk - en næring i vekst
Prosjektstatus:
Bevilgning
Prosjektperiode:
01.07.2013 - 30.06.2016
Geografi:
Norge/OSLO
Fagområder:
Landbruks- og fiskerifag/Fiskerifag/Akvakultur
Prosjektnummer:
225065