Gå direkte til innhold
 

Direct effects of sugar on development of cardiovascular disease

Based on epidemiological studies, elevated sugar consumption and chronic hyperglycemia is a risk factor for cardiovascular disease, partly due to systemic effects such as insulin resistance in hepatic, adipose and muscle tissue, type 2 diabetes, obesity a nd/or hypertension. However, it has now become clear that elevated glucose and fructose levels may have direct and deleterious effects on all cells in the body, including macrophages and cardiomyocytes. The mechanism with particular relevance to the curr ent study is a unique type of glycosylation (O-GlcNAc) to cellular proteins. This protein modification is regulated by nutrient intake, affecting the function of cellular proteins analogous to protein phosphorylation. Hyperglycemic increase in the abundan ce of O-GlcNac modifications have been shown to play an important role in the development of insulin resistance, glucose toxicity and vascular dysfunction. During a 6 months stay in the laboratory of professor Gerald W. Hart, Johns Hopkins School of Medic ine, Baltimore, USA, phD student Qiong Fan in our laboratory aim to use cutting-edge mass spectrometric (MS) techniques to identify novel glucose- and fructose-induced O-GlcNAc modified proteins in macrophages and cardiomyocytes. A selection of identifie d proteins will be further studied (at UoO) for their biological role i cardiovascular disease development.

Prosjektleder:
Line Mariann Grønning-Wang
Institusjon:
UoH-sektor/Universitetet i Oslo/Institutt for medisinske basal
Aktivitetsnavn:
Mobilitet Norge-USA Canada
Prosjektstatus:
Bevilgning
Prosjektperiode:
30.01.2013 - 01.08.2013
Geografi:
Norge/OSLO
Fagområder:
Matematikk og naturvitenskap/Basale biofag/Molekylærbiologi
Prosjektnummer:
224917