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Modelling of a membrane-bound metabolon

With this project, we intend to demonstrate that, with the right combination of molecular modelling techniques, it is possible to predict the structure of hyper-complexes structures. We have chosen as a model system a membrane-bound metabolon involved in the production of small plant metabolites sparking a growing interest because of their potential beneficial effects on human health: the flavonoids. Our project will establish computational protocols useful for the investigation of membrane-bound metabolo ns in general. Five research groups from four different countries are involved in this project and will exchange knowledge and competences on in silico methods for protein-protein interactions, enzymatic reactivity and membrane-protein interactions. A key point for the accurate reconstruction of such a macromolecular system is a reliable description of the interactions between the protein involved in the complex and the cell membrane. This is the focus of the collaboration we intend to initiate between th e group of Prof. Antonczak (Univ. of Nice) and the group of Dr.Reuter (Univ. of Bergen).

Prosjektleder:
Nathalie Reuter
Institusjon:
UoH-sektor/Universitetet i Bergen/Molekylærbiologisk institutt
Aktivitetsnavn:
Samarb.progr. Norge Frankrike
Prosjektstatus:
Bevilgning
Prosjektperiode:
01.01.2013 - 31.12.2013
Geografi:
Norge/HORDALAND/BERGEN
Fagområder:
Matematikk og naturvitenskap/Basale biofag
Prosjektnummer:
221631