Fish and seafood are the main dietary contributors to marine n-3 PUFAs, but fish also contain vitamin D, selenium, iodine and high quality proteins. So far the majority of the studies on marine nutrients, has focused on single components. Thus, recommenda tions are mostly based on studies using single nutrients (i.e. fish oil), whilst there is a lack of documentation on health effects of fish consumption in humans. There is a global increase in life style diseases, and according to WHO, better nutrition is important to prevent life style diseases. This highlights the significance of systematic intervention studies investigating the risk-reducing effects of increased fish consumption, and animal studies to elucidate mechanisms. Overall, our proposal will f ocus on metabolic and mental health, including population-based studies, systematic intervention studies, and mechanistic studies. Among the primary end points are learning abilities in children, thermic and satiety effects in young adults, glucose tolera nce in overweight adults, and functional outcome in the elderly. Both farmed salmon, white fish and pelagic fish will be included in the interventions. Animal studies will be carried out to elucidate underlying mechanisms. In the population-based studies we will make use of epidemiological data from middle-aged and elderly to study the effect of dietary fish intake on the development of metabolic syndrome, diabetes type II and cardiovascular disease. From a longitudinal population study of pregnant women, we will investigate the associations between seafood intake, maternal postpartum depression, and infant development. The interdisciplinary project group consists of physicians, nutritionists and psychologists, and our results will contribute to establish a solid framework for assessing the role of seafood in relation to the prevention of life style diseases, for nutritional recommendations and for health claims relevant for the fish industry as well as consumers.
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