Novel web-based and mobile technologies are expected to offer huge opportunities for reconfiguring healthcare towards more patient-centric models for service provision. This project will study the challenges and opportunities that utilization of these tec hnologies poses to the existing digital information infrastructures (the "installed base") in the healthcare sector, and also how the existing infrastructure influences the new technologies: on the one hand the new technologies should build on and utilize the existing information available, and on the other hand, the existing information infrastructures should be flexible enough to allow new service models to emerge. Achieving such a productive interplay is not trivial, as new service models may create te nsions with the existing installed base, both in terms of non-compatibility with established technologies, organizational forms and economic models. In addition, the information infrastructures should also be able to harness the potential for further inno vations arising in an open innovation system where the patients as users have a different role. In order to investigate such tensions, the project will draw on relevant theories from the cross-disciplinary Information Systems field, as well as Organizat ional Theory and Economics. By conducting multiple longitudinal qualitative case studies in hospitals where diverse novel technologies are actually used, we contribute to an improved understanding of the conditions for realizing the transformative potenti al of these technologies, and for making productive use of the existing information infrastructures. By identifying core qualities of "responsive architectures", we seek to define the infrastructure-related requirements, approaches and strategies that can accomodate, support and stimulate such technology-enabled innovative provision of patient-oriented health services. This covers elements of a technological, organizational and economic nature.