The objective of the SALMODIS research project is to improve the scientific basis for decision-making related to regulations and intervention strategies for disease control in the salmon farming industry. It will support government and industry in evaluat ing constraints and cost-effectiveness of strategies with regard to their effects on economic, environmental and social dimensions.Fish diseases present short- and long-term challenges to the sustainability of the aquaculture industry and the community as a whole. Sea lice alone cost the global industry 300 million EUR per year. In addition to these economic influences, diseases, directly or indirectly, affect ecological and social sustainability issues. Authorities, industry, and other stakeholders ack nowledge the urgent need to address diseases through more proactive and coordinated control strategies.The SALMODIS-project is based on a broad and existing platform of knowledge, integrating research partners as well as major industry actors, covering social sciences, epidemiology, biology, economics, and enabling technologies to address the problem from a holistic, long-term perspective. The project requires a novel and thorough integration, which will be organised in three work packages that contribu te toward the unification of sustainability dimensions and stakeholder interests with knowledge domains and models.WP 1 will develop methods to evaluate cost-effectiveness and trade-offs with respect to the impacts of disease control.WP 2 deals with t he aspects of model integration and coordination required to use models from multiple domains. Two historic disease cases, covering sea lice and Pancreas Disease, will be explored.WP 3 focuses on combining results from WP1 and WP2 into decision support tools addressing a strategic level, enabling forecasts and scenario evaluation.The SALMODIS-project will result in significant contributions towards a future-oriented knowledge based management of salmon farming.