The neurological diseases myasthenia gravis (MG), multiple sclerosis (MS) and epilepsy can influence pregnancy, the process of giving birth and the child. Genetic factors, pathogenic mechanisms, disease symptoms and therapy can be responsible. The Medical Birth Registry of Norway contains information on all more than 2 million Norwegian births since 1967. Records can be combined with detailed hospital information, and with novel immunological, genetic and electrophysiological disease-related data, partly developed by our group. Through national and regional health registries such as The National MS Registry, Bergen Child Study, The Norwegian Mother and Child Cohort Study and The Norwegian Conscripts Service, we will examine outcome for the children by mot hers with MG, MS and epilepsy. The approval to link registry and hospital data has been obtained from nearly all MG mothers and from the majority with MS. The project will create and strengthen a neuroepidemiological national network. It will be undertake n in an international context, using the EUROCAT network for congenital malformations and include existing EU-project networks. The national and international partners will constitute a reference group. The major aims are to assess the risk during pregnan cy, birth and for the child short- and long-term when mother has MG, MS or epilepsy, and to define the importance of specific disease factors to be able to predict the risk in the individual patient. The influence of therapy before annd during pregnancy w ill be examined. Outcome will be compared before and after debut of disease. All three selected disorders commonly present with first symptoms during child-bearing age. Influence of the disease in mother and father can be compared, and similarly the outc ome in mothers and healthy sisters of mothers. All work will be undertaken within the confines of the Norwegian Data Protective Directive, and only after the full approval of the Regional Research Ethics Committee.